Plasmid CpG Depletion Improves Degree and Duration of Tumor Gene Expression After Intravenous Administration of Polyplexes

PURPOSE: Tumor gene expression after the intravenous (i.v.) administration of current polymer-based gene delivery systems is generally low and short-lived. Immune stimulatory CpG dinucleotides, present within the plasmid DNA of the polyplexes are likely to contribute to this. The effect of CpG repla...

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Detalles Bibliográficos
Autores principales: de Wolf, Holger K., Johansson, Nina, Thong, Anh-Thy, Snel, Cor J., Mastrobattista, Enrico, Hennink, Wim E., Storm, Gert
Formato: Texto
Lenguaje:English
Publicado: Springer US 2008
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440937/
https://www.ncbi.nlm.nih.gov/pubmed/18317886
http://dx.doi.org/10.1007/s11095-008-9558-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440937/
https://www.ncbi.nlm.nih.gov/pubmed/18317886
http://dx.doi.org/10.1007/s11095-008-9558-7

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