A simple algorithm for quantifying DNA methylation levels on multiple independent CpG sites in bisulfite genomic sequencing electropherograms

DNA methylation at cytosines is a widely studied epigenetic modification. Methylation is commonly detected using bisulfite modification of DNA followed by PCR and additional techniques such as restriction digestion or sequencing. These additional techniques are either laborious, require specialized...

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Detalles Bibliográficos
Autores principales: Leakey, Tatiana I., Zielinski, Jerzy, Siegfried, Rachel N., Siegel, Eric R., Fan, Chun-Yang, Cooney, Craig A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441810/
https://www.ncbi.nlm.nih.gov/pubmed/18480118
http://dx.doi.org/10.1093/nar/gkn210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441810/
https://www.ncbi.nlm.nih.gov/pubmed/18480118
http://dx.doi.org/10.1093/nar/gkn210

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