PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

Here we describe the expression and function of a HIF-1-regulated protein pyruvate dehydrogenase kinase-1 (PDK-1) in head and neck squamous cancer (HNSCC). Using RNAi to downregulate hypoxia-inducible PDK-1, we found that lactate and pyruvate excretion after 16–48 h of hypoxia was suppressed to norm...

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Detalles Bibliográficos
Autores principales: Wigfield, S M, Winter, S C, Giatromanolaki, A, Taylor, J, Koukourakis, M L, Harris, A L
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441961/
https://www.ncbi.nlm.nih.gov/pubmed/18542064
http://dx.doi.org/10.1038/sj.bjc.6604356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441961/
https://www.ncbi.nlm.nih.gov/pubmed/18542064
http://dx.doi.org/10.1038/sj.bjc.6604356

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