Cargando…

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

Here we describe the expression and function of a HIF-1-regulated protein pyruvate dehydrogenase kinase-1 (PDK-1) in head and neck squamous cancer (HNSCC). Using RNAi to downregulate hypoxia-inducible PDK-1, we found that lactate and pyruvate excretion after 16–48 h of hypoxia was suppressed to norm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wigfield, S M, Winter, S C, Giatromanolaki, A, Taylor, J, Koukourakis, M L, Harris, A L
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2008
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441961/ https://www.ncbi.nlm.nih.gov/pubmed/18542064 http://dx.doi.org/10.1038/sj.bjc.6604356

Ejemplares similares

Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia
por: Koukourakis, M I, et al.
Publicado: (2010)

Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis
por: Koukourakis, M I, et al.
Publicado: (2003)

Identification of a hypoxia-regulated miRNA signature in bladder cancer and a role for miR-145 in hypoxia-dependent apoptosis
por: Blick, C, et al.
Publicado: (2015)

Expression of carbonic anhydrase 9, a potential intrinsic marker of hypoxia, is associated with poor prognosis in oesophageal squamous cell carcinoma
por: Tanaka, N, et al.
Publicado: (2008)

Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer
por: Shaw, R J, et al.
Publicado: (2009)

Spindle cell morphology is related to poor prognosis in vulvar squamous cell carcinoma
por: Trietsch, M D, et al.
Publicado: (2013)

Prolactin receptor is a negative prognostic factor in patients with squamous cell carcinoma of the head and neck
por: Bauernhofer, T, et al.
Publicado: (2011)

Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma
por: Zhang, H, et al.
Publicado: (2008)

Oncogenic role of PDK4 in human colon cancer cells
por: Leclerc, D, et al.
Publicado: (2017)

Downregulation of EGFR in hypoxic, diffusion-limited areas of squamous cell carcinomas of the head and neck
por: Mayer, Arnulf, et al.
Publicado: (2016)

Ron tyrosine kinase receptor synergises with EGFR to confer adverse features in head and neck squamous cell carcinoma
por: Keller, J, et al.
Publicado: (2013)

Overexpression of stathmin in oral squamous-cell carcinoma: correlation with tumour progression and poor prognosis
por: Kouzu, Y, et al.
Publicado: (2006)

Overexpression of glypican-1 implicates poor prognosis and their chemoresistance in oesophageal squamous cell carcinoma
por: Hara, Hisashi, et al.
Publicado: (2016)

Overexpression of TMPRSS4 in non-small cell lung cancer is associated with poor prognosis in patients with squamous histology
por: Larzabal, L, et al.
Publicado: (2011)

PDK1 inhibition is a novel therapeutic target in multiple myeloma
por: Fujiwara, S, et al.
Publicado: (2013)

Analysis of exhaled breath for diagnosing head and neck squamous cell carcinoma: a feasibility study
por: Gruber, M, et al.
Publicado: (2014)

Mesenchymal stem cells are enriched in head neck squamous cell carcinoma, correlates with tumour size and inhibit T-cell proliferation
por: Liotta, F, et al.
Publicado: (2015)

Collagen type XI α1 facilitates head and neck squamous cell cancer growth and invasion
por: Sok, J C, et al.
Publicado: (2013)

Overexpression of nucleostemin contributes to an advanced malignant phenotype and a poor prognosis in oral squamous cell carcinoma
por: Yoshida, R, et al.
Publicado: (2014)

SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma
por: Lee, S H, et al.
Publicado: (2014)

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia
por: Maftouh, M, et al.
Publicado: (2014)

Quantitative methylation analyses of resection margins predict local recurrences and disease-specific deaths in patients with head and neck squamous cell carcinomas
por: Tan, H K, et al.
Publicado: (2008)

PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound
por: Cen, L, et al.
Publicado: (2007)

Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma
por: Takemoto, S, et al.
Publicado: (2009)

Prognostic significance of cortactin levels in head and neck squamous cell carcinoma: comparison with epidermal growth factor receptor status
por: Hofman, P, et al.
Publicado: (2008)

Hypoxia-inducible factor-1α and -2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosis
por: Rasheed, S, et al.
Publicado: (2009)

Neutrophils: driving progression and poor prognosis in hepatocellular carcinoma?
por: Margetts, Jane, et al.
Publicado: (2018)

Downregulation of HLA Class I molecules in the tumour is associated with a poor prognosis in patients with oesophageal squamous cell carcinoma
por: Mizukami, Y, et al.
Publicado: (2008)

Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression
por: Canel, M, et al.
Publicado: (2008)

ERCC1 expression as a predictive marker of squamous cell carcinoma of the head and neck treated with cisplatin-based concurrent chemoradiation
por: Jun, H J, et al.
Publicado: (2008)

Slice cultures from head and neck squamous cell carcinoma: a novel test system for drug susceptibility and mechanisms of resistance
por: Gerlach, M M, et al.
Publicado: (2014)

Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma
por: Nohata, N, et al.
Publicado: (2013)

Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients
por: Jie, H-B, et al.
Publicado: (2013)

Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer
por: Hussain, S A, et al.
Publicado: (2007)

Diagnosis of head-and-neck cancer from exhaled breath
por: Hakim, M, et al.
Publicado: (2011)

Detection of occult carcinomatous diffusion in lymph nodes from head and neck squamous cell carcinoma using real-time RT–PCR detection of cytokeratin 19 mRNA
por: Tao, L, et al.
Publicado: (2006)

Microsatellite mutations in buccal cells are associated with aging and head and neck carcinoma
por: Slebos, R J C, et al.
Publicado: (2008)

Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin–integrin signalling in head and neck squamous cell carcinoma
por: Kinoshita, T, et al.
Publicado: (2013)

Arpin downregulation in breast cancer is associated with poor prognosis
por: Lomakina, Maria E, et al.
Publicado: (2016)

Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer
por: Pichler, M, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_hts93k506gf07pk7au41do9obm