Galpha(s)-coupled receptor signaling actively down-regulates α(4)β(1)-integrin affinity: A possible mechanism for cell de-adhesion

BACKGROUND: Activation of integrins in response to inside-out signaling serves as a basis for leukocyte arrest on endothelium, and migration of immune cells. Integrin-dependent adhesion is controlled by the conformational state of the molecule (i.e. change in the affinity for the ligand and molecula...

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Detalles Bibliográficos
Autores principales: Chigaev, Alexandre, Waller, Anna, Amit, Or, Sklar, Larry A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442041/
https://www.ncbi.nlm.nih.gov/pubmed/18534032
http://dx.doi.org/10.1186/1471-2172-9-26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442041/
https://www.ncbi.nlm.nih.gov/pubmed/18534032
http://dx.doi.org/10.1186/1471-2172-9-26

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