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Galpha(s)-coupled receptor signaling actively down-regulates α(4)β(1)-integrin affinity: A possible mechanism for cell de-adhesion
BACKGROUND: Activation of integrins in response to inside-out signaling serves as a basis for leukocyte arrest on endothelium, and migration of immune cells. Integrin-dependent adhesion is controlled by the conformational state of the molecule (i.e. change in the affinity for the ligand and molecula...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442041/ https://www.ncbi.nlm.nih.gov/pubmed/18534032 http://dx.doi.org/10.1186/1471-2172-9-26 |