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A Close Association of RyRs with Highly Dense Clusters of Ca(2+)-activated Cl(−) Channels Underlies the Activation of STICs by Ca(2+) Sparks in Mouse Airway Smooth Muscle
Ca(2+) sparks are highly localized, transient releases of Ca(2+) from sarcoplasmic reticulum through ryanodine receptors (RyRs). In smooth muscle, Ca(2+) sparks trigger spontaneous transient outward currents (STOCs) by opening nearby clusters of large-conductance Ca(2+)-activated K(+) channels, and...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442178/ https://www.ncbi.nlm.nih.gov/pubmed/18591421 http://dx.doi.org/10.1085/jgp.200709933 |