Loss of miRNA biogenesis induces p19(Arf)-p53 signaling and senescence in primary cells

Dicer, an enzyme involved in microRNA (miRNA) maturation, is required for proper cell differentiation and embryogenesis in mammals. Recent evidence indicates that Dicer and miRNA may also regulate tumorigenesis. To better characterize the role of miRNA in primary cell growth, we generated Dicer-cond...

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Detalles Bibliográficos
Autores principales: Mudhasani, Rajini, Zhu, Zhiqing, Hutvagner, Gyorgy, Eischen, Christine M., Lyle, Stephen, Hall, Lisa L., Lawrence, Jeanne B., Imbalzano, Anthony N., Jones, Stephen N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442212/
https://www.ncbi.nlm.nih.gov/pubmed/18591425
http://dx.doi.org/10.1083/jcb.200802105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442212/
https://www.ncbi.nlm.nih.gov/pubmed/18591425
http://dx.doi.org/10.1083/jcb.200802105

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