Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake

Copy number (CN) variation (CNV) has been shown to be common in regions of the genome coding for immune-related genes, and thus impacts upon polygenic autoimmunity. Low CN of FCGR3B has recently been associated with systemic lupus erythematosus (SLE). FcγRIIIb is a glycosylphosphatidylinositol-linke...

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Detalles Bibliográficos
Autores principales: Willcocks, Lisa C., Lyons, Paul A., Clatworthy, Menna R., Robinson, James I., Yang, Wanling, Newland, Stephen A., Plagnol, Vincent, McGovern, Naomi N., Condliffe, Alison M., Chilvers, Edwin R., Adu, Dwomoa, Jolly, Elaine C., Watts, Richard, Lau, Yu Lung, Morgan, Ann W., Nash, Gerard, Smith, Kenneth G.C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442635/
https://www.ncbi.nlm.nih.gov/pubmed/18559452
http://dx.doi.org/10.1084/jem.20072413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442635/
https://www.ncbi.nlm.nih.gov/pubmed/18559452
http://dx.doi.org/10.1084/jem.20072413

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