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Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages
Increased evidence suggests that cancer-associated inflammation supports tumor growth and progression. We have previously shown that semaphorin 4D (Sema4D), a ligand produced by different cell types, is a proangiogenic molecule that acts by binding to its receptor, plexin B1, expressed on endothelia...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442644/ https://www.ncbi.nlm.nih.gov/pubmed/18559453 http://dx.doi.org/10.1084/jem.20072602 |
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author | Sierra, Jose Rafael Corso, Simona Caione, Luisa Cepero, Virna Conrotto, Paolo Cignetti, Alessandro Piacibello, Wanda Kumanogoh, Atsushi Kikutani, Hitoshi Comoglio, Paolo Maria Tamagnone, Luca Giordano, Silvia |
author_facet | Sierra, Jose Rafael Corso, Simona Caione, Luisa Cepero, Virna Conrotto, Paolo Cignetti, Alessandro Piacibello, Wanda Kumanogoh, Atsushi Kikutani, Hitoshi Comoglio, Paolo Maria Tamagnone, Luca Giordano, Silvia |
author_sort | Sierra, Jose Rafael |
collection | PubMed |
description | Increased evidence suggests that cancer-associated inflammation supports tumor growth and progression. We have previously shown that semaphorin 4D (Sema4D), a ligand produced by different cell types, is a proangiogenic molecule that acts by binding to its receptor, plexin B1, expressed on endothelial cells (Conrotto, P., D. Valdembri, S. Corso, G. Serini, L. Tamagnone, P.M. Comoglio, F. Bussolino, and S. Giordano. 2005. Blood. 105:4321–4329). The present work highlights the role of Sema4D produced by the tumor microenvironment on neoplastic angiogenesis. We show that in an environment lacking Sema4D, the ability of cancer cells to generate tumor masses and metastases is severely impaired. This condition can be explained by a defective vascularization inside the tumor. We demonstrate that tumor-associated macrophages (TAMs) are the main cells producing Sema4D within the tumor stroma and that their ability to produce Sema4D is critical for tumor angiogenesis and vessel maturation. This study helps to explain the protumoral role of inflammatory cells of the tumor stroma and leads to the identification of an angiogenic molecule that might be a novel therapeutic target. |
format | Text |
id | pubmed-2442644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-24426442009-01-07 Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages Sierra, Jose Rafael Corso, Simona Caione, Luisa Cepero, Virna Conrotto, Paolo Cignetti, Alessandro Piacibello, Wanda Kumanogoh, Atsushi Kikutani, Hitoshi Comoglio, Paolo Maria Tamagnone, Luca Giordano, Silvia J Exp Med Articles Increased evidence suggests that cancer-associated inflammation supports tumor growth and progression. We have previously shown that semaphorin 4D (Sema4D), a ligand produced by different cell types, is a proangiogenic molecule that acts by binding to its receptor, plexin B1, expressed on endothelial cells (Conrotto, P., D. Valdembri, S. Corso, G. Serini, L. Tamagnone, P.M. Comoglio, F. Bussolino, and S. Giordano. 2005. Blood. 105:4321–4329). The present work highlights the role of Sema4D produced by the tumor microenvironment on neoplastic angiogenesis. We show that in an environment lacking Sema4D, the ability of cancer cells to generate tumor masses and metastases is severely impaired. This condition can be explained by a defective vascularization inside the tumor. We demonstrate that tumor-associated macrophages (TAMs) are the main cells producing Sema4D within the tumor stroma and that their ability to produce Sema4D is critical for tumor angiogenesis and vessel maturation. This study helps to explain the protumoral role of inflammatory cells of the tumor stroma and leads to the identification of an angiogenic molecule that might be a novel therapeutic target. The Rockefeller University Press 2008-07-07 /pmc/articles/PMC2442644/ /pubmed/18559453 http://dx.doi.org/10.1084/jem.20072602 Text en © 2008 Sierra et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Articles Sierra, Jose Rafael Corso, Simona Caione, Luisa Cepero, Virna Conrotto, Paolo Cignetti, Alessandro Piacibello, Wanda Kumanogoh, Atsushi Kikutani, Hitoshi Comoglio, Paolo Maria Tamagnone, Luca Giordano, Silvia Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages |
title | Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages |
title_full | Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages |
title_fullStr | Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages |
title_full_unstemmed | Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages |
title_short | Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages |
title_sort | tumor angiogenesis and progression are enhanced by sema4d produced by tumor-associated macrophages |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442644/ https://www.ncbi.nlm.nih.gov/pubmed/18559453 http://dx.doi.org/10.1084/jem.20072602 |
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