Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness

Cancer is sporadic in nature, characterized by an initial clonal oncogenic event and usually a long latency. When and how it subverts the immune system is unknown. We show, in a model of sporadic immunogenic cancer, that tumor-specific tolerance closely coincides with the first tumor antigen recogni...

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Detalles Bibliográficos
Autores principales: Willimsky, Gerald, Czéh, Melinda, Loddenkemper, Christoph, Gellermann, Johanna, Schmidt, Karin, Wust, Peter, Stein, Harald, Blankenstein, Thomas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442645/
https://www.ncbi.nlm.nih.gov/pubmed/18573907
http://dx.doi.org/10.1084/jem.20072016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442645/
https://www.ncbi.nlm.nih.gov/pubmed/18573907
http://dx.doi.org/10.1084/jem.20072016

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