Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

Interleukin-7 (IL-7) is a homeostatic cytokine for resting T cells with increasing serum and tissue levels during T cell depletion. In preclinical studies, IL-7 therapy exerts marked stimulating effects on T cell immune reconstitution in mice and primates. First-in-human clinical studies of recombin...

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Detalles Bibliográficos
Autores principales: Sportès, Claude, Hakim, Frances T., Memon, Sarfraz A., Zhang, Hua, Chua, Kevin S., Brown, Margaret R., Fleisher, Thomas A., Krumlauf, Michael C., Babb, Rebecca R., Chow, Catherine K., Fry, Terry J., Engels, Julie, Buffet, Renaud, Morre, Michel, Amato, Robert J., Venzon, David J., Korngold, Robert, Pecora, Andrew, Gress, Ronald E., Mackall, Crystal L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442646/
https://www.ncbi.nlm.nih.gov/pubmed/18573906
http://dx.doi.org/10.1084/jem.20071681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442646/
https://www.ncbi.nlm.nih.gov/pubmed/18573906
http://dx.doi.org/10.1084/jem.20071681

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