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UV-Light Exposed Prion Protein Fails to Form Amyloid Fibrils
Amyloid fibril formation involves three steps; structural perturbation, nucleation and elongation. We have investigated amyloidogenesis using prion protein as a model system and UV-light as a structural perturbant. We find that UV-exposed prion protein fails to form amyloid fibrils. Interestingly, i...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442654/ https://www.ncbi.nlm.nih.gov/pubmed/18628989 http://dx.doi.org/10.1371/journal.pone.0002688 |