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UV-Light Exposed Prion Protein Fails to Form Amyloid Fibrils

Amyloid fibril formation involves three steps; structural perturbation, nucleation and elongation. We have investigated amyloidogenesis using prion protein as a model system and UV-light as a structural perturbant. We find that UV-exposed prion protein fails to form amyloid fibrils. Interestingly, i...

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Detalles Bibliográficos
Autores principales:	Thakur, Abhay Kumar, Rao, Ch Mohan
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442654/ https://www.ncbi.nlm.nih.gov/pubmed/18628989 http://dx.doi.org/10.1371/journal.pone.0002688

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