Isolation, purification, and full NMR assignments of cyclopamine from Veratrum californicum

BACKGROUND: The Hedgehog signaling pathway is essential for embryogenesis and for tissue homeostasis in the adult. However, it may induce malignancies in a number of tissues when constitutively activated, and it may also have a role in other forms of normal and maladaptive growth. Cyclopamine, a nat...

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Detalles Bibliográficos
Autores principales: Oatis, John E, Brunsfeld, Pam, Rushing, James W, Moeller, Peter D, Bearden, Daniel W, Gallien, Thomas N, Cooper, George
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442831/
https://www.ncbi.nlm.nih.gov/pubmed/18577213
http://dx.doi.org/10.1186/1752-153X-2-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442831/
https://www.ncbi.nlm.nih.gov/pubmed/18577213
http://dx.doi.org/10.1186/1752-153X-2-12

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