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Isolation, purification, and full NMR assignments of cyclopamine from Veratrum californicum
BACKGROUND: The Hedgehog signaling pathway is essential for embryogenesis and for tissue homeostasis in the adult. However, it may induce malignancies in a number of tissues when constitutively activated, and it may also have a role in other forms of normal and maladaptive growth. Cyclopamine, a nat...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442831/ https://www.ncbi.nlm.nih.gov/pubmed/18577213 http://dx.doi.org/10.1186/1752-153X-2-12 |