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Defects in Actin Dynamics Lead to an Autoinflammatory Condition through the Upregulation of CXCL5

BACKGROUND: Destrin (DSTN) is a member of the ADF/cofilin family of proteins and is an important regulator of actin dynamics. The primary function of destrin is to depolymerize filamentous actin into its monomeric form and promote filament severing. While progress has been made in understanding the...

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Detalles Bibliográficos
Autores principales: Verdoni, Angela M., Smith, Richard S., Ikeda, Akihiro, Ikeda, Sakae
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442876/
https://www.ncbi.nlm.nih.gov/pubmed/18628996
http://dx.doi.org/10.1371/journal.pone.0002701