Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model

BACKGROUND AND PURPOSE: Drug-induced prolongation of the QT interval can lead to torsade de pointes, a life-threatening ventricular arrhythmia. Finding appropriate assays from among the plethora of options available to predict reliably this serious adverse effect in humans remains a challenging issu...

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Detalles Bibliográficos
Autores principales: Yao, X, Anderson, D L, Ross, S A, Lang, D G, Desai, B Z, Cooper, D C, Wheelan, P, McIntyre, M S, Bergquist, M L, MacKenzie, K I, Becherer, J D, Hashim, M A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442905/
https://www.ncbi.nlm.nih.gov/pubmed/18587422
http://dx.doi.org/10.1038/bjp.2008.267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442905/
https://www.ncbi.nlm.nih.gov/pubmed/18587422
http://dx.doi.org/10.1038/bjp.2008.267

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