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The Effects on Toxicity of Circadian Patterning of Continuous Hepatic Artery Infusion

Long term continuous hepatic artery infusion of FUDR was carried out in 34 rats. In the animals who received a constant infusion schedule of 15mg/kg/day all died of toxicity with a mean survival of 9.3 days. If the pattern of the continuous infusion was changed so that over 60% of the infusion was g...

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Detalles Bibliográficos
Autores principales: Kemeny, M. Margaret, Alava, Galo, Oliver, Jorge M., Smith, Fred B.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1992
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442957/
https://www.ncbi.nlm.nih.gov/pubmed/1387318
http://dx.doi.org/10.1155/1992/28702