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Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF
The Microphthalmia-associated transcription factor (MITF) is an important regulator of cell-type specific functions in melanocytic cells. MITF is essential for the survival of pigmented cells, but whereas high levels of MITF drive melanocyte differentiation, lower levels are required to permit proli...
Autores principales: | Wellbrock, Claudia, Rana, Sareena, Paterson, Hugh, Pickersgill, Helen, Brummelkamp, Thijn, Marais, Richard |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2444043/ https://www.ncbi.nlm.nih.gov/pubmed/18628967 http://dx.doi.org/10.1371/journal.pone.0002734 |
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