Inefficient Nef-Mediated Downmodulation of CD3 and MHC-I Correlates with Loss of CD4(+) T Cells in Natural SIV Infection

Recent data suggest that Nef-mediated downmodulation of TCR-CD3 may protect SIVsmm-infected sooty mangabeys (SMs) against the loss of CD4(+) T cells. However, the mechanisms underlying this protective effect remain unclear. To further assess the role of Nef in nonpathogenic SIV infection, we cloned...

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Detalles Bibliográficos
Autores principales: Schindler, Michael, Schmökel, Jan, Specht, Anke, Li, Hui, Münch, Jan, Khalid, Mohammad, Sodora, Donald L., Hahn, Beatrice H., Silvestri, Guido, Kirchhoff, Frank
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2444047/
https://www.ncbi.nlm.nih.gov/pubmed/18636106
http://dx.doi.org/10.1371/journal.ppat.1000107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2444047/
https://www.ncbi.nlm.nih.gov/pubmed/18636106
http://dx.doi.org/10.1371/journal.ppat.1000107

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