Cargando…

Inefficient Nef-Mediated Downmodulation of CD3 and MHC-I Correlates with Loss of CD4(+) T Cells in Natural SIV Infection

Recent data suggest that Nef-mediated downmodulation of TCR-CD3 may protect SIVsmm-infected sooty mangabeys (SMs) against the loss of CD4(+) T cells. However, the mechanisms underlying this protective effect remain unclear. To further assess the role of Nef in nonpathogenic SIV infection, we cloned...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schindler, Michael, Schmökel, Jan, Specht, Anke, Li, Hui, Münch, Jan, Khalid, Mohammad, Sodora, Donald L., Hahn, Beatrice H., Silvestri, Guido, Kirchhoff, Frank
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2444047/ https://www.ncbi.nlm.nih.gov/pubmed/18636106 http://dx.doi.org/10.1371/journal.ppat.1000107

Ejemplares similares

Nef-mediated TCR-CD3 and MHC-I down-modulation prevents CD4+ T cell depletion in natural SIV infection
por: Schindler, Michael, et al.
Publicado: (2006)

Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion
por: Joas, Simone, et al.
Publicado: (2020)

Link between Primate Lentiviral Coreceptor Usage and Nef Function
por: Schmökel, Jan, et al.
Publicado: (2013)

Conservation of Nef function across highly diverse lineages of SIVsmm
por: Schmökel, Jan, et al.
Publicado: (2009)

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3
por: Manrique, Santiago, et al.
Publicado: (2017)

Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease
por: Tschulena, Ulrich, et al.
Publicado: (2011)

Maturation of protective immunity induced by SIVΔnef correlates with differential expression of transcription factors in SIV-specific CD8+ T cells
por: Billingsley, JM, et al.
Publicado: (2012)

Nef interferes with development of thymic T cell precursors: differential mechanisms in HIV and SIV
por: Meuwissen, PJ, et al.
Publicado: (2011)

Characterization of CD8(+) T Cell Differentiation following SIVΔnef Vaccination by Transcription Factor Expression Profiling
por: Billingsley, James M., et al.
Publicado: (2015)

CD8(+) lymphocyte control of SIV infection during antiretroviral therapy
por: Cao, Youfang, et al.
Publicado: (2018)

Tetherin downmodulation by SIVmac Nef lost with the H196Q escape variant is restored by an upstream variant
por: Schouest, Blake, et al.
Publicado: (2020)

P03-09. Preserved adaptive immune responses and limited immune activation in CD4-low SIV-positive sooty mangabeys
por: Mir, KD, et al.
Publicado: (2009)

Human Immunodeficiency Virus Type 1-Associated Cd4 Downmodulation
por: Geleziunas, Romas, et al.
Publicado: (1994)

Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques
por: Roberts, Emily R., et al.
Publicado: (2016)

Location and Dynamics of the Immunodominant CD8 T Cell Response to SIVΔnef Immunization and SIVmac251 Vaginal Challenge
por: Sasikala-Appukuttan, Arun K., et al.
Publicado: (2013)

Correction: Characterization of CD8+ T Cell Differentiation following SIVΔnef Vaccination by Transcription Factor Expression Profiling
Publicado: (2015)

Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2
por: Hopfensperger, Kristina, et al.
Publicado: (2020)

Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection
por: Adnan, Sama, et al.
Publicado: (2016)

Immune recognition of HLA molecules downmodulates CD8 expression on cytotoxic T lymphocytes
Publicado: (1991)

CD8 T Cell Response Maturation Defined by Anentropic Specificity and Repertoire Depth Correlates with SIVΔnef-induced Protection
por: Adnan, Sama, et al.
Publicado: (2015)

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms
por: Van Nuffel, Anouk, et al.
Publicado: (2013)

Alterations in intracellular potassium concentration by HIV-1 and SIV Nef
por: Choi, Bongkun, et al.
Publicado: (2008)

The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence
por: Strongin, Zachary, et al.
Publicado: (2022)

Correction: CD8 T Cell Response Maturation Defined by Anentropic Specificity and Repertoire Depth Correlates with SIVΔnef-induced Protection
Publicado: (2015)

Oxidative downmodulation of T cell-mediated cytotoxicity
por: Wabnitz, Guido H, et al.
Publicado: (2016)

Why Don't CD8+ T Cells Reduce the Lifespan of SIV-Infected Cells In Vivo?
por: Elemans, Marjet, et al.
Publicado: (2011)

Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers
por: Blanco, Belén, et al.
Publicado: (2022)

Characterization of Nef expression in different brain regions of SIV-infected macaques
por: Yarandi, Shadan S., et al.
Publicado: (2020)

Low levels of SIV infection in sooty mangabey central-memory CD4+ T-cells is associated with limited CCR5 expression
por: Paiardini, Mirko, et al.
Publicado: (2011)

Distinct transcriptome profiles of Gag-specific CD8+ T cells temporally correlated with the protection elicited by SIVΔnef live attenuated vaccine
por: Lu, Wuxun, et al.
Publicado: (2017)

Rectal HSV-2 Infection May Increase Rectal SIV Acquisition Even in the Context of SIVΔnef Vaccination
por: Guerra-Pérez, Natalia, et al.
Publicado: (2016)

Decreased plasticity of coreceptor use by CD4-independent SIV Envs that emerge in vivo
por: Francella, Nicholas, et al.
Publicado: (2013)

Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread
por: Mesner, Dejan, et al.
Publicado: (2020)

Profound CD4(+)/CCR5(+) T cell expansion is induced by CD8(+) lymphocyte depletion but does not account for accelerated SIV pathogenesis
por: Okoye, Afam, et al.
Publicado: (2009)

Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategies
por: Ramírez-Fernández, Ángel, et al.
Publicado: (2022)

The loss of CCR6+ and CD161+ CD4+ T cell homeostasis contributes to disease progression in SIV-infected rhesus macaques
por: McGary, Colleen S., et al.
Publicado: (2017)

Loss and regain of SIV control upon CD8+ cell depletion in vivo in SIV-controller macaques is not associated with efficient SIV specific CD8+ T-cells
por: Hamimi, C, et al.
Publicado: (2012)

Nef gene evolution from a single transmitted strain in acute SIV infection
por: Bimber, Benjamin N, et al.
Publicado: (2009)

Multifunctional Double-negative T Cells in Sooty Mangabeys Mediate T-helper Functions Irrespective of SIV Infection
por: Sundaravaradan, Vasudha, et al.
Publicado: (2013)

Localized Populations of CD8(low/−) MHC Class I Tetramer(+) SIV-Specific T Cells in Lymphoid Follicles and Genital Epithelium
por: Hong, Jung Joo, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_33sa97oet8o77iqi6s5c8p2pae