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A Cytoplasmic Domain Mutation in ClC-Kb Affects Long-Distance Communication Across the Membrane
BACKGROUND: ClC-Kb and ClC-Ka are homologous chloride channels that facilitate chloride homeostasis in the kidney and inner ear. Disruption of ClC-Kb leads to Bartter's Syndrome, a kidney disease. A point mutation in ClC-Kb, R538P, linked to Bartter's Syndrome and located in the C-terminal...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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Public Library of Science
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447174/ https://www.ncbi.nlm.nih.gov/pubmed/18648499 http://dx.doi.org/10.1371/journal.pone.0002746 |