Mitochondrial Ca(2+) Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs

Dysregulation of intracellular Ca(2+) homeostasis may underlie amyloid β peptide (Aβ) toxicity in Alzheimer's Disease (AD) but the mechanism is unknown. In search for this mechanism we found that Aβ(1–42) oligomers, the assembly state correlating best with cognitive decline in AD, but not Aβ fi...

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Detalles Bibliográficos
Autores principales: Sanz-Blasco, Sara, Valero, Ruth A., Rodríguez-Crespo, Ignacio, Villalobos, Carlos, Núñez, Lucía
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447871/
https://www.ncbi.nlm.nih.gov/pubmed/18648507
http://dx.doi.org/10.1371/journal.pone.0002718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447871/
https://www.ncbi.nlm.nih.gov/pubmed/18648507
http://dx.doi.org/10.1371/journal.pone.0002718

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