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Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies

Lamin A mutations cause many diseases, including cardiomyopathies and Progeria Syndrome. The covalent attachment of small ubiquitin-like modifier (SUMO) polypeptides regulates the function of many proteins. Until now, no examples of human disease-causing mutations that occur within a sumoylation con...

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Detalles Bibliográficos
Autores principales: Zhang, Yu-Qian, Sarge, Kevin D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447889/
https://www.ncbi.nlm.nih.gov/pubmed/18606848
http://dx.doi.org/10.1083/jcb.200712124