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Playing both sides: nucleophosmin between tumor suppression and oncogenesis
Nucleophosmin (NPM) is frequently mutated in acute myeloid leukemias and is thought to act as both a proto-oncogene and a tumor suppressor. Although genetic and molecular evidence has shed light on the mechanisms of NPM-mediated tumor suppression, the potential role of NPM mutants as oncogenes remai...
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| Formato: | Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447893/ https://www.ncbi.nlm.nih.gov/pubmed/18625839 http://dx.doi.org/10.1083/jcb.200806069 |