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Playing both sides: nucleophosmin between tumor suppression and oncogenesis

Nucleophosmin (NPM) is frequently mutated in acute myeloid leukemias and is thought to act as both a proto-oncogene and a tumor suppressor. Although genetic and molecular evidence has shed light on the mechanisms of NPM-mediated tumor suppression, the potential role of NPM mutants as oncogenes remai...

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Detalles Bibliográficos
Autor principal: Di Fiore, Pier Paolo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447893/
https://www.ncbi.nlm.nih.gov/pubmed/18625839
http://dx.doi.org/10.1083/jcb.200806069