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Playing both sides: nucleophosmin between tumor suppression and oncogenesis

Nucleophosmin (NPM) is frequently mutated in acute myeloid leukemias and is thought to act as both a proto-oncogene and a tumor suppressor. Although genetic and molecular evidence has shed light on the mechanisms of NPM-mediated tumor suppression, the potential role of NPM mutants as oncogenes remai...

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Detalles Bibliográficos
Autor principal: Di Fiore, Pier Paolo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447893/
https://www.ncbi.nlm.nih.gov/pubmed/18625839
http://dx.doi.org/10.1083/jcb.200806069
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author Di Fiore, Pier Paolo
author_facet Di Fiore, Pier Paolo
author_sort Di Fiore, Pier Paolo
collection PubMed
description Nucleophosmin (NPM) is frequently mutated in acute myeloid leukemias and is thought to act as both a proto-oncogene and a tumor suppressor. Although genetic and molecular evidence has shed light on the mechanisms of NPM-mediated tumor suppression, the potential role of NPM mutants as oncogenes remains ill defined. Now, new data provide a straightforward mechanism for this latter function, as NPM is shown to regulate the stability and the function of MYC. Remarkably, the same leitmotif of “placing a critical cell regulator in the wrong place at the wrong time” appears to underscore all the cancer-promoting activities of mutated NPM.
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spelling pubmed-24478932009-01-14 Playing both sides: nucleophosmin between tumor suppression and oncogenesis Di Fiore, Pier Paolo J Cell Biol Reviews Nucleophosmin (NPM) is frequently mutated in acute myeloid leukemias and is thought to act as both a proto-oncogene and a tumor suppressor. Although genetic and molecular evidence has shed light on the mechanisms of NPM-mediated tumor suppression, the potential role of NPM mutants as oncogenes remains ill defined. Now, new data provide a straightforward mechanism for this latter function, as NPM is shown to regulate the stability and the function of MYC. Remarkably, the same leitmotif of “placing a critical cell regulator in the wrong place at the wrong time” appears to underscore all the cancer-promoting activities of mutated NPM. The Rockefeller University Press 2008-07-14 /pmc/articles/PMC2447893/ /pubmed/18625839 http://dx.doi.org/10.1083/jcb.200806069 Text en © 2008 Di Fiore This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Di Fiore, Pier Paolo
Playing both sides: nucleophosmin between tumor suppression and oncogenesis
title Playing both sides: nucleophosmin between tumor suppression and oncogenesis
title_full Playing both sides: nucleophosmin between tumor suppression and oncogenesis
title_fullStr Playing both sides: nucleophosmin between tumor suppression and oncogenesis
title_full_unstemmed Playing both sides: nucleophosmin between tumor suppression and oncogenesis
title_short Playing both sides: nucleophosmin between tumor suppression and oncogenesis
title_sort playing both sides: nucleophosmin between tumor suppression and oncogenesis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447893/
https://www.ncbi.nlm.nih.gov/pubmed/18625839
http://dx.doi.org/10.1083/jcb.200806069
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