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Playing both sides: nucleophosmin between tumor suppression and oncogenesis
Nucleophosmin (NPM) is frequently mutated in acute myeloid leukemias and is thought to act as both a proto-oncogene and a tumor suppressor. Although genetic and molecular evidence has shed light on the mechanisms of NPM-mediated tumor suppression, the potential role of NPM mutants as oncogenes remai...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447893/ https://www.ncbi.nlm.nih.gov/pubmed/18625839 http://dx.doi.org/10.1083/jcb.200806069 |
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author | Di Fiore, Pier Paolo |
author_facet | Di Fiore, Pier Paolo |
author_sort | Di Fiore, Pier Paolo |
collection | PubMed |
description | Nucleophosmin (NPM) is frequently mutated in acute myeloid leukemias and is thought to act as both a proto-oncogene and a tumor suppressor. Although genetic and molecular evidence has shed light on the mechanisms of NPM-mediated tumor suppression, the potential role of NPM mutants as oncogenes remains ill defined. Now, new data provide a straightforward mechanism for this latter function, as NPM is shown to regulate the stability and the function of MYC. Remarkably, the same leitmotif of “placing a critical cell regulator in the wrong place at the wrong time” appears to underscore all the cancer-promoting activities of mutated NPM. |
format | Text |
id | pubmed-2447893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-24478932009-01-14 Playing both sides: nucleophosmin between tumor suppression and oncogenesis Di Fiore, Pier Paolo J Cell Biol Reviews Nucleophosmin (NPM) is frequently mutated in acute myeloid leukemias and is thought to act as both a proto-oncogene and a tumor suppressor. Although genetic and molecular evidence has shed light on the mechanisms of NPM-mediated tumor suppression, the potential role of NPM mutants as oncogenes remains ill defined. Now, new data provide a straightforward mechanism for this latter function, as NPM is shown to regulate the stability and the function of MYC. Remarkably, the same leitmotif of “placing a critical cell regulator in the wrong place at the wrong time” appears to underscore all the cancer-promoting activities of mutated NPM. The Rockefeller University Press 2008-07-14 /pmc/articles/PMC2447893/ /pubmed/18625839 http://dx.doi.org/10.1083/jcb.200806069 Text en © 2008 Di Fiore This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Reviews Di Fiore, Pier Paolo Playing both sides: nucleophosmin between tumor suppression and oncogenesis |
title | Playing both sides: nucleophosmin between tumor suppression and oncogenesis |
title_full | Playing both sides: nucleophosmin between tumor suppression and oncogenesis |
title_fullStr | Playing both sides: nucleophosmin between tumor suppression and oncogenesis |
title_full_unstemmed | Playing both sides: nucleophosmin between tumor suppression and oncogenesis |
title_short | Playing both sides: nucleophosmin between tumor suppression and oncogenesis |
title_sort | playing both sides: nucleophosmin between tumor suppression and oncogenesis |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447893/ https://www.ncbi.nlm.nih.gov/pubmed/18625839 http://dx.doi.org/10.1083/jcb.200806069 |
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