TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

Synthetic inhibitor of apoptosis (IAP) antagonists induce degradation of IAP proteins such as cellular IAP1 (cIAP1), activate nuclear factor κB (NF-κB) signaling, and sensitize cells to tumor necrosis factor α (TNFα). The physiological relevance of these discoveries to cIAP1 function remains undeter...

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Detalles Bibliográficos
Autores principales: Vince, James E., Chau, Diep, Callus, Bernard, Wong, W. Wei-Lynn, Hawkins, Christine J., Schneider, Pascal, McKinlay, Mark, Benetatos, Christopher A., Condon, Stephen M., Chunduru, Srinivas K., Yeoh, George, Brink, Robert, Vaux, David L., Silke, John
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447903/
https://www.ncbi.nlm.nih.gov/pubmed/18606850
http://dx.doi.org/10.1083/jcb.200801010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447903/
https://www.ncbi.nlm.nih.gov/pubmed/18606850
http://dx.doi.org/10.1083/jcb.200801010

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