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Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine

Alterations in the tumour suppressor p53 have been reported in tumour-associated stromal cells; however, the consequence of these alterations has not been elucidated. We investigated p53 status and responses to p53-activating drugs using tumour-associated stromal cells from A375 melanoma and PC3 pro...

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Detalles Bibliográficos
Autores principales: Dudley, A C, Shih, S-C, Cliffe, A R, Hida, K, Klagsbrun, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453010/
https://www.ncbi.nlm.nih.gov/pubmed/18594537
http://dx.doi.org/10.1038/sj.bjc.6604465