Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

DNA double-strand breaks (DSBs) can be processed by the Mre11–Rad50–Nbs1 (MRN) complex, which is essential to promote ataxia telangiectasia-mutated (ATM) activation. However, the molecular mechanisms linking MRN activity to ATM are not fully understood. Here, using Xenopus laevis egg extract we show...

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Detalles Bibliográficos
Autores principales: Jazayeri, Ali, Balestrini, Alessia, Garner, Elizabeth, Haber, James E, Costanzo, Vincenzo
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453060/
https://www.ncbi.nlm.nih.gov/pubmed/18596698
http://dx.doi.org/10.1038/emboj.2008.128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453060/
https://www.ncbi.nlm.nih.gov/pubmed/18596698
http://dx.doi.org/10.1038/emboj.2008.128

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