Activation of Steroid and Xenobiotic Receptor (SXR, NR1I2) and Its Orthologs in Laboratory, Toxicologic, and Genome Model Species

BACKGROUND: Nuclear receptor subfamily 1, group I, member 2 (NR1I2), commonly known as steroid and xenobiotic receptor (SXR) in humans, is a key ligand-dependent transcription factor responsible for the regulation of xenobiotic, steroid, and bile acid metabolism. The ligand-binding domain is princip...

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Detalles Bibliográficos
Autores principales: Milnes, Matthew R., Garcia, Adriana, Grossman, Emily, Grün, Felix, Shiotsugu, Jason, Tabb, Michelle M., Kawashima, Yukio, Katsu, Yoshinao, Watanabe, Hajime, Iguchi, Taisen, Blumberg, Bruce
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453155/
https://www.ncbi.nlm.nih.gov/pubmed/18629309
http://dx.doi.org/10.1289/ehp.10853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453155/
https://www.ncbi.nlm.nih.gov/pubmed/18629309
http://dx.doi.org/10.1289/ehp.10853

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