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Retroviral Integration Process in the Human Genome: Is It Really Non-Random? A New Statistical Approach

Retroviral vectors are widely used in gene therapy to introduce therapeutic genes into patients' cells, since, once delivered to the nucleus, the genes of interest are stably inserted (integrated) into the target cell genome. There is now compelling evidence that integration of retroviral vecto...

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Detalles Bibliográficos
Autores principales: Ambrosi, Alessandro, Cattoglio, Claudia, Di Serio, Clelia
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453317/
https://www.ncbi.nlm.nih.gov/pubmed/18688267
http://dx.doi.org/10.1371/journal.pcbi.1000144