Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis

OBJECTIVE—We have developed a novel platform for display and delivery of bioactive peptides that links the biological properties of the peptide to the pharmacokinetic properties of an antibody. Peptides engineered in the MIMETIBODY platform have improved biochemical and biophysical properties that a...

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Detalles Bibliográficos
Autores principales: Picha, Kristen M., Cunningham, Mark R., Drucker, Daniel J., Mathur, Ashok, Ort, Tatiana, Scully, Michael, Soderman, Avery, Spinka-Doms, Tracy, Stojanovic-Susulic, Vedrana, Ann Thomas, Beth, O'Neil, Karyn T.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453616/
https://www.ncbi.nlm.nih.gov/pubmed/18426860
http://dx.doi.org/10.2337/db07-1775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453616/
https://www.ncbi.nlm.nih.gov/pubmed/18426860
http://dx.doi.org/10.2337/db07-1775

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