Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion : A New Mechanism for Fat-Induced Impairment of β-Cell Function

OBJECTIVE—Fructose-1,6-bisphosphatase (FBPase) is a gluconeogenic enzyme that is upregulated in islets or pancreatic β-cell lines exposed to high fat. However, whether specific β-cell upregulation of FBPase can impair insulin secretory function is not known. The objective of this study therefore is...

Descripción completa

Detalles Bibliográficos
Autores principales: Kebede, Melkam, Favaloro, Jenny, Gunton, Jenny E., Laybutt, D. Ross, Shaw, Margaret, Wong, Nicole, Fam, Barbara C., Aston-Mourney, Kathryn, Rantzau, Christian, Zulli, Anthony, Proietto, Joseph, Andrikopoulos, Sofianos
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453625/
https://www.ncbi.nlm.nih.gov/pubmed/18375435
http://dx.doi.org/10.2337/db07-1326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453625/
https://www.ncbi.nlm.nih.gov/pubmed/18375435
http://dx.doi.org/10.2337/db07-1326

Ejemplares similares