Diabetes Susceptibility in the Canadian Oji-Cree Population Is Moderated by Abnormal mRNA Processing of HNF1A G319S Transcripts

OBJECTIVE—The G319S HNF1A variant is associated with an increased risk of type 2 diabetes in the Canadian Oji-Cree population. We hypothesized that the variant site at the 3′ end of exon 4 might influence splicing and characterized mRNA transcripts to investigate the mutational mechanism underlying...

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Detalles Bibliográficos
Autores principales: Harries, Lorna W., Sloman, Melissa J., Sellers, Elizabeth A.C., Hattersley, Andrew T., Ellard, Sian
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453634/
https://www.ncbi.nlm.nih.gov/pubmed/18586913
http://dx.doi.org/10.2337/db07-1633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453634/
https://www.ncbi.nlm.nih.gov/pubmed/18586913
http://dx.doi.org/10.2337/db07-1633

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