Cargando…

UMF-078: A modified flubendazole with potent macrofilaricidal activity against Onchocerca ochengi in African cattle

BACKGROUND: Human onchocerciasis or river blindness, caused by the filarial nematode Onchocerca volvulus, is currently controlled using the microfilaricidal drug, ivermectin. However, ivermectin does not kill adult O. volvulus, and in areas with less than 65% ivermectin coverage of the population, t...

Descripción completa

Detalles Bibliográficos
Autores principales:	deC Bronsvoort, Barend M, Makepeace, Benjamin L, Renz, Alfons, Tanya, Vincent N, Fleckenstein, Lawrence, Ekale, David, Trees, Alexander J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464590/ https://www.ncbi.nlm.nih.gov/pubmed/18570639 http://dx.doi.org/10.1186/1756-3305-1-18

Ejemplares similares

Repeated high doses of avermectins cause prolonged sterilisation, but do not kill, Onchocerca ochengi adult worms in African cattle
por: deC Bronsvoort, Barend M, et al.
Publicado: (2005)

Development and validation of an Onchocerca ochengi adult male worm gerbil model for macrofilaricidal drug screening
por: Cho-Ngwa, Fidelis, et al.
Publicado: (2019)

Flubendazole as a macrofilaricide: History and background
por: Geary, Timothy G., et al.
Publicado: (2019)

Full mitochondrial and nuclear genome comparison confirms that Onchocerca sp. “Siisa” is Onchocerca ochengi
por: Jaleta, Tegegn G., et al.
Publicado: (2018)

A worm's best friend: recruitment of neutrophils by Wolbachia confounds eosinophil degranulation against the filarial nematode Onchocerca ochengi
por: Hansen, Rowena D. E., et al.
Publicado: (2011)

Lipid profiling of the filarial nematodes Onchocerca volvulus, Onchocerca ochengi and Litomosoides sigmodontis reveals the accumulation of nematode-specific ether phospholipids in the host
por: Wewer, Vera, et al.
Publicado: (2017)

Onchocerca - infected cattle produce strong antibody responses to excretory-secretory proteins released from adult male Onchocerca ochengi worms
por: Boursou, Djafsia, et al.
Publicado: (2018)

Emodepside targets SLO-1 channels of Onchocerca ochengi and induces broad anthelmintic effects in a bovine model of onchocerciasis
por: Bah, Germanus S., et al.
Publicado: (2021)

Onchocerca armillata contains the endosymbiotic bacterium Wolbachia and elicits a limited inflammatory response
por: Neary, Joseph M., et al.
Publicado: (2010)

Galectins from Onchocerca ochengi and O. volvulus and their immune recognition by Wistar rats, Gudali zebu cattle and human hosts
por: Ngwasiri, Ngwafu Nancy, et al.
Publicado: (2021)

Correction to: Galectins from Onchocerca ochengi and O. volvulus and their immune recognition by Wistar rats, Gudali zebu cattle and human hosts
por: Ngwasiri, Ngwafu Nancy, et al.
Publicado: (2021)

Profiling the macrofilaricidal effects of flubendazole on adult female Brugia malayi using RNAseq
por: O'Neill, Maeghan, et al.
Publicado: (2016)

Effects of an injectable long-acting formulation of ivermectin on Onchocerca ochengi in zebu cattle
por: Boussinesq, Michel, et al.
Publicado: (2020)

Selective activity of extracts of Margaritaria discoidea and Homalium africanum on Onchocerca ochengi
por: Cho-Ngwa, Fidelis, et al.
Publicado: (2010)

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds
por: Hübner, Marc P., et al.
Publicado: (2019)

Characterization of a novel glycosylated glutathione transferase of Onchocerca ochengi, closest relative of the human river blindness parasite
por: Rose, Clair, et al.
Publicado: (2019)

Development and validation of an Onchocerca ochengi microfilarial hamster model for onchocerciasis drug screens
por: Mbah, Glory Enjong, et al.
Publicado: (2016)

Co-Administration of Adjuvanted Recombinant Ov-103 and Ov-RAL-2 Vaccines Confer Protection against Natural Challenge in A Bovine Onchocerca ochengi Infection Model of Human Onchocerciasis
por: Luu, Lisa, et al.
Publicado: (2022)

Pharmacokinetic comparison of different flubendazole formulations in pigs: A further contribution to its development as a macrofilaricide molecule
por: Ceballos, L., et al.
Publicado: (2015)

Antifilarial Activity of the Methanolic Extract of Indigofera tinctoria (Fabaceae) on Bovine Parasites (Onchocerca ochengi)
por: Rakwa, Enock Enock, et al.
Publicado: (2022)

Stage-specific Proteomes from Onchocerca ochengi, Sister Species of the Human River Blindness Parasite, Uncover Adaptations to a Nodular Lifestyle
por: Armstrong, Stuart D., et al.
Publicado: (2016)

In vitro anti-Onchocerca ochengi activities of extracts and chromatographic fractions of Craterispermum laurinum and Morinda lucida
por: Samje, Moses, et al.
Publicado: (2014)

Discrimination between Onchocerca volvulus and O. ochengi filarial larvae in Simulium damnosum (s.l.) and their distribution throughout central Ghana using a versatile high-resolution speciation assay
por: Doyle, Stephen R., et al.
Publicado: (2016)

Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle With Onchocerca ochengi
por: Zhan, Bin, et al.
Publicado: (2022)

Histopathological evaluation of Onchocerca volvulus nodules by microscopy and by digital image analysis for the study of macrofilaricidal drug efficacy
por: Fischer, Kerstin, et al.
Publicado: (2023)

Filaricidal activities on Onchocerca ochengi and Loa loa, toxicity and phytochemical screening of extracts of Tragia benthami and Piper umbellatum
por: Cho-Ngwa, Fidelis, et al.
Publicado: (2016)

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro
por: Hübner, Marc P., et al.
Publicado: (2020)

Filaricidal properties of Lantana camara and Tamarindus indica extracts, and Lantadene A from L. camara against Onchocerca ochengi and Loa loa
por: Ngwewondo, Adela, et al.
Publicado: (2018)

Macrofilaricidal Activity after Doxycycline Only Treatment of Onchocerca volvulus in an Area of Loa loa Co-Endemicity: A Randomized Controlled Trial
por: Turner, Joseph D., et al.
Publicado: (2010)

Further evidence of the cross-reactivity of the Binax NOW® Filariasis ICT cards to non-Wuchereria bancrofti filariae: experimental studies with Loa loa and Onchocerca ochengi
por: Wanji, Samuel, et al.
Publicado: (2016)

Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models
por: Sjoberg, Hanna T., et al.
Publicado: (2019)

Phytochemical analysis and in vitro anthelmintic activity of Lophira lanceolata (Ochnaceae) on the bovine parasite Onchocerca ochengi and on drug resistant strains of the free-living nematode Caenorhabditis elegans
por: Kalmobé, Justin, et al.
Publicado: (2017)

Onchocerca ochengi male worms implanted in SCID mice and Gerbil: Relationship between microfilaridermia status of cows, nodular worm viability and fertility and worm survival in the rodents
por: Akumtoh, Desmond N., et al.
Publicado: (2021)

Estimation of the impact of Fasciola hepatica infection on time taken for UK beef cattle to reach slaughter weight
por: Mazeri, Stella, et al.
Publicado: (2017)

Ongoing Transmission of Onchocerca volvulus after 25 Years of Annual Ivermectin Mass Treatments in the Vina du Nord River Valley, in North Cameroon
por: Eisenbarth, Albert, et al.
Publicado: (2016)

Macrofilaricides and onchocerciasis control, mathematical modelling of the prospects for elimination
por: Alley, William Soumbey, et al.
Publicado: (2001)

Pyrvinium Pamoate and Structural Analogs Are Early Macrofilaricide Leads
por: Gunderson, Emma L., et al.
Publicado: (2022)

Multivariate chemogenomic screening prioritizes new macrofilaricidal leads
por: Wheeler, Nicolas J., et al.
Publicado: (2023)

Extracellular Onchocerca-derived small RNAs in host nodules and blood
por: Quintana, Juan F, et al.
Publicado: (2015)

Individual exposure to Simulium bites and intensity of Onchocerca volvulus infection
por: Jacobi, C A, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_q19tuu3dp48710sffmlam5lt9f