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A simple and robust method for connecting small-molecule drugs using gene-expression signatures
BACKGROUND: Interaction of a drug or chemical with a biological system can result in a gene-expression profile or signature characteristic of the event. Using a suitably robust algorithm these signatures can potentially be used to connect molecules with similar pharmacological or toxicological prope...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464610/ https://www.ncbi.nlm.nih.gov/pubmed/18518950 http://dx.doi.org/10.1186/1471-2105-9-258 |