Structural characterization of a human Fc fragment engineered for lack of effector functions

The first three-dimensional structure of a human Fc fragment genetically engineered for the elimination of its ability to mediate antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity is reported. When introduced into the lower hinge and C(H)2 domain of human IgG1 molec...

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Detalles Bibliográficos
Autores principales: Oganesyan, Vaheh, Gao, Changshou, Shirinian, Lena, Wu, Herren, Dall’Acqua, William F.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2467532/
https://www.ncbi.nlm.nih.gov/pubmed/18560159
http://dx.doi.org/10.1107/S0907444908007877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2467532/
https://www.ncbi.nlm.nih.gov/pubmed/18560159
http://dx.doi.org/10.1107/S0907444908007877

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