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CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer

Opioid agonists have a broad range of effects on cells of the immune system, including modulation of the inflammatory response, and opioid and chemokine receptors are co-expressed by many white cells. Hetero-oligomerization of the human DOP opioid and chemokine CXCR2 receptors could be detected foll...

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Detalles Bibliográficos
Autores principales: Parenty, Geraldine, Appelbe, Shirley, Milligan, Graeme
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474558/
https://www.ncbi.nlm.nih.gov/pubmed/18307412
http://dx.doi.org/10.1042/BJ20071689