Notch and Presenilin Regulate Cellular Expansion and Cytokine Secretion but Cannot Instruct Th1/Th2 Fate Acquisition

Recent reports suggested that Delta1, 4 and Jagged1, 2 possessed the ability to instruct CD4(+) T cell into selection of Th1 or Th2 fates, respectively, although the underlying mechanism endowing the cleaved Notch receptor with memory of ligand involved in its activation remains elusive. To examine...

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Detalles Bibliográficos
Autores principales: Ong, Chin-Tong, Sedy, John R., Murphy, Kenneth M., Kopan, Raphael
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474705/
https://www.ncbi.nlm.nih.gov/pubmed/18665263
http://dx.doi.org/10.1371/journal.pone.0002823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474705/
https://www.ncbi.nlm.nih.gov/pubmed/18665263
http://dx.doi.org/10.1371/journal.pone.0002823

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