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Mdm2 Induces Mono-Ubiquitination of FOXO4

BACKGROUND: The Forkhead box O (FOXO) class of transcription factors are involved in the regulation of several cellular responses including cell cycle progression and apoptosis. Furthermore, in model organisms FOXOs act as tumor suppressors and affect aging. Previously, we noted that FOXOs and p53 a...

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Detalles Bibliográficos
Autores principales: Brenkman, Arjan B., de Keizer, Peter L. J., van den Broek, Niels J. F., Jochemsen, A. G., Burgering, Boudewijn M. Th.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475507/
https://www.ncbi.nlm.nih.gov/pubmed/18665269
http://dx.doi.org/10.1371/journal.pone.0002819