The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA–topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts

Crotonaldehyde is a representative α,β-unsaturated aldehyde endowed of mutagenic and carcinogenic properties related to its propensity to react with DNA. Cyclic crotonaldehyde-derived deoxyguanosine (CrA-PdG) adducts can undergo ring opening in duplex DNA to yield a highly reactive aldehydic moiety....

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Detalles Bibliográficos
Autores principales: Dexheimer, Thomas S., Kozekova, Albena, Rizzo, Carmelo J., Stone, Michael P., Pommier, Yves
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475617/
https://www.ncbi.nlm.nih.gov/pubmed/18550580
http://dx.doi.org/10.1093/nar/gkn334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475617/
https://www.ncbi.nlm.nih.gov/pubmed/18550580
http://dx.doi.org/10.1093/nar/gkn334

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