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Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex
The multisubunit Mediator (MED) complex bridges DNA-bound transcriptional regulators to the RNA polymerase II (PolII) initiation machinery. In yeast, the 25 MED subunits are distributed within three core subcomplexes and a separable kinase module composed of Med12, Med13 and the Cdk8-CycC pair thoug...
Autor principal: | Bourbon, Henri-Marc |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475620/ https://www.ncbi.nlm.nih.gov/pubmed/18515835 http://dx.doi.org/10.1093/nar/gkn349 |
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