A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining

DNA-dependent protein kinase (DNA-PK) is an essential component of the nonhomologous end joining pathway (NHEJ), responsible for the repair of DNA double-strand breaks. Ku binds a DSB and recruits the catalytic subunit, DNA-PKcs, where it is activated once the kinase is bound to the DSB. The precise...

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Detalles Bibliográficos
Autores principales: Pawelczak, Katherine S., Turchi, John J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475626/
https://www.ncbi.nlm.nih.gov/pubmed/18515838
http://dx.doi.org/10.1093/nar/gkn344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475626/
https://www.ncbi.nlm.nih.gov/pubmed/18515838
http://dx.doi.org/10.1093/nar/gkn344

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