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Octreotide, a Somatostatin Analogue, Fails to Inhibit Hypoxia-induced Retinal Neovascularization in the Neonatal Rat

Objective: Octreotide, a somatostatin analogue, has been shown to prevent angiogenesis in diverse in vitro models. We evaluated its effect on retinal neovascularization in vivo, using a neonatal rat retinopathy model. Methods: We used, on alternating days, hypoxia (10% O(2)) and hyperoxia (50% O(2))...

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Detalles Bibliográficos
Autores principales: Averbukh, Edward, Halpert, Michael, Yanko, Ravit, Yanko, Lutza, Peèr, Jacob, Levinger, Samuel, Flyvbjerg, Allan, Raz, Itamar
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2477751/
https://www.ncbi.nlm.nih.gov/pubmed/11469389
http://dx.doi.org/10.1155/EDR.2000.39