The contribution of large genomic deletions at the CDKN2A locus to the burden of familial melanoma

Mutations in two genes encoding cell cycle regulatory proteins have been shown to cause familial cutaneous malignant melanoma (CMM). About 20% of melanoma-prone families bear a point mutation in the CDKN2A locus at 9p21, which encodes two unrelated proteins, p16(INK4a) and p14(ARF). Rare mutations i...

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Detalles Bibliográficos
Autores principales: Lesueur, F, de Lichy, M, Barrois, M, Durand, G, Bombled, J, Avril, M-F, Chompret, A, Boitier, F, Lenoir, G M, Bressac-de Paillerets, B
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2480975/
https://www.ncbi.nlm.nih.gov/pubmed/18612309
http://dx.doi.org/10.1038/sj.bjc.6604470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2480975/
https://www.ncbi.nlm.nih.gov/pubmed/18612309
http://dx.doi.org/10.1038/sj.bjc.6604470

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