Bid Participates in Genotoxic Drug-Induced Apoptosis of HeLa Cells and Is Essential for Death Receptor Ligands' Apoptotic and Synergistic Effects

BACKGROUND: The BH3-only protein Bid is an important component of death receptor-mediated caspase activation. Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors. Bid has also been reported to be cleaved by other pr...

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Detalles Bibliográficos
Autores principales: Köhler, Barbara, Anguissola, Sergio, Concannon, Caoimhin G., Rehm, Markus, Kögel, Donat, Prehn, Jochen H. M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481399/
https://www.ncbi.nlm.nih.gov/pubmed/18665234
http://dx.doi.org/10.1371/journal.pone.0002844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481399/
https://www.ncbi.nlm.nih.gov/pubmed/18665234
http://dx.doi.org/10.1371/journal.pone.0002844

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