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ACTH Inhibits bTREK-1 K(+) Channels through Multiple cAMP-dependent Signaling Pathways

Bovine adrenal zona fasciculata (AZF) cells express bTREK-1 K(+) channels that set the resting membrane potential and function pivotally in the physiology of cortisol secretion. Inhibition of these K(+) channels by adrenocorticotropic hormone (ACTH) or cAMP is coupled to depolarization and Ca(2+) en...

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Detalles Bibliográficos
Autores principales: Liu, Haiyan, Enyeart, Judith A., Enyeart, John J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483331/
https://www.ncbi.nlm.nih.gov/pubmed/18663135
http://dx.doi.org/10.1085/jgp.200810003