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α-Scorpion Toxin Impairs a Conformational Change that Leads to Fast Inactivation of Muscle Sodium Channels

α-Scorpion toxins bind in a voltage-dependent way to site 3 of the sodium channels, which is partially formed by the loop connecting S3 and S4 segments of domain IV, slowing down fast inactivation. We have used Ts3, an α-scorpion toxin from the Brazilian scorpion Tityus serrulatus, to analyze the ef...

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Detalles Bibliográficos
Autores principales: Campos, Fabiana V., Chanda, Baron, Beirão, Paulo S.L., Bezanilla, Francisco
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483334/
https://www.ncbi.nlm.nih.gov/pubmed/18663133
http://dx.doi.org/10.1085/jgp.200809995