Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB

RNA interference (RNAi) acts constitutively to silence the innate immune response, and innate immunity genes are misregulated in Dicer-deficient Caenorhabditis elegans. Here, we show that inhibition of Dicer expression by RNAi in human cells up-regulates major histocompatibility complex class I–rela...

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Detalles Bibliográficos
Autores principales: Tang, Kai-Fu, Ren, Hong, Cao, Jia, Zeng, Gui-Li, Xie, Jing, Chen, Min, Wang, Lu, He, Cai-Xia
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483517/
https://www.ncbi.nlm.nih.gov/pubmed/18644891
http://dx.doi.org/10.1083/jcb.200801169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483517/
https://www.ncbi.nlm.nih.gov/pubmed/18644891
http://dx.doi.org/10.1083/jcb.200801169

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